Search

BIO DESIGN

pISSN 1225-8962
eISSN 2287-982X

Article

Article

Original Article

Split Viewer

Phys. Ther. Korea 2022; 29(3): 200-207

Published online August 20, 2022

https://doi.org/10.12674/ptk.2022.29.3.200

© Korean Research Society of Physical Therapy

Reliable Prognostic Cardiopulmonary Function Variables in 110 Patients With Acute Ischemic Heart Disease

Jeong Jae Lee1,2,3 , PT, MSc, Chan-hee Park1,2 , PT, MSc, Joshua (Sung) Hyun You1,2 , PT, PhD

1Sports Movement Artificial-Intelligence Robotics Technology (SMART) Institute, 2Department of Physical Therapy, Yonsei University, Wonju, 3Rehabilitation Team, Myongji Hospital, Goyang, Korea

Correspondence to: Joshua (Sung) Hyun You
E-mail: neurorehab@yonsei.ac.kr
https://orcid.org/0000-0001-9931-2466

Received: June 28, 2022; Revised: August 5, 2022; Accepted: August 6, 2022

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: The oxygen uptake efficiency slope (OUES) is the most important index for accurately measuring cardiopulmonary function in patients with acute ischemic heart disease. However, the relationship between the OUES variables and important cardiopulmonary function parameters remain unelucidated for patients with acute ischemic heart disease, which accounts for the largest proportion of heart disease. Objects: The present cross sectional clinical study aimed to determine the multiple relationships among the cardiopulmonary function variables mentioned above in adults with acute ischemic heart disease.
Methods: A convenience sample of 110 adult inpatients with ischemic heart disease (age: 57.4 ± 11.3 y; 95 males, 15 females) was enrolled at the hospital cardiac rehabilitation center. The correlation between the important cardiopulmonary function indicators including peak oxygen uptake (VO2 peak), minute ventilation (VE)/carbon dioxide production (VCO2) slope, heart rate recovery (HRR), and ejection fraction (EF) and OUES was confirmed.
Results: This study showed that OUES was highly correlated with VO2 peak, VE/VCO2 slope, and HRR parameters.
Conclusion: The OUES can be used as an accurate indicator for cardiopulmonary function. There are other factors that influence aerobic capacity besides EF, so there is no correlation with EF. Effective cardiopulmonary rehabilitation programs can be designed based on OUES during submaximal exercise in patients with acute ischemic heart disease.

Keywords: Cardiac rehabilitation, Heart disease, Heart rate, Ventilation

Article

Original Article

Phys. Ther. Korea 2022; 29(3): 200-207

Published online August 20, 2022 https://doi.org/10.12674/ptk.2022.29.3.200

Copyright © Korean Research Society of Physical Therapy.

Reliable Prognostic Cardiopulmonary Function Variables in 110 Patients With Acute Ischemic Heart Disease

Jeong Jae Lee1,2,3 , PT, MSc, Chan-hee Park1,2 , PT, MSc, Joshua (Sung) Hyun You1,2 , PT, PhD

1Sports Movement Artificial-Intelligence Robotics Technology (SMART) Institute, 2Department of Physical Therapy, Yonsei University, Wonju, 3Rehabilitation Team, Myongji Hospital, Goyang, Korea

Correspondence to:Joshua (Sung) Hyun You
E-mail: neurorehab@yonsei.ac.kr
https://orcid.org/0000-0001-9931-2466

Received: June 28, 2022; Revised: August 5, 2022; Accepted: August 6, 2022

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: The oxygen uptake efficiency slope (OUES) is the most important index for accurately measuring cardiopulmonary function in patients with acute ischemic heart disease. However, the relationship between the OUES variables and important cardiopulmonary function parameters remain unelucidated for patients with acute ischemic heart disease, which accounts for the largest proportion of heart disease. Objects: The present cross sectional clinical study aimed to determine the multiple relationships among the cardiopulmonary function variables mentioned above in adults with acute ischemic heart disease.
Methods: A convenience sample of 110 adult inpatients with ischemic heart disease (age: 57.4 ± 11.3 y; 95 males, 15 females) was enrolled at the hospital cardiac rehabilitation center. The correlation between the important cardiopulmonary function indicators including peak oxygen uptake (VO2 peak), minute ventilation (VE)/carbon dioxide production (VCO2) slope, heart rate recovery (HRR), and ejection fraction (EF) and OUES was confirmed.
Results: This study showed that OUES was highly correlated with VO2 peak, VE/VCO2 slope, and HRR parameters.
Conclusion: The OUES can be used as an accurate indicator for cardiopulmonary function. There are other factors that influence aerobic capacity besides EF, so there is no correlation with EF. Effective cardiopulmonary rehabilitation programs can be designed based on OUES during submaximal exercise in patients with acute ischemic heart disease.

Keywords: Cardiac rehabilitation, Heart disease, Heart rate, Ventilation

Fig 1.

Figure 1.Higher and lower oxygen uptake efficiency slope. (A) Steeper slope, higher oxygen uptake efficiency slope; (B) shallower slope, lower oxygen uptake efficiency slope.
Physical Therapy Korea 2022; 29: 200-207https://doi.org/10.12674/ptk.2022.29.3.200

Fig 2.

Figure 2.VO2 peak and OUES correlation. VO2 peak, peak oxygen uptake; OUES, oxygen uptake efficiency slope.
Physical Therapy Korea 2022; 29: 200-207https://doi.org/10.12674/ptk.2022.29.3.200

Fig 3.

Figure 3.VE/VCO2 slope and OUES correlation. VE/VCO2, minute ventilation/carbon dioxide production; OUES, oxygen uptake efficiency slope.
Physical Therapy Korea 2022; 29: 200-207https://doi.org/10.12674/ptk.2022.29.3.200

Fig 4.

Figure 4.HRR and OUES correlation. HRR, heart rate recovery; OUES, oxygen uptake efficiency slope.
Physical Therapy Korea 2022; 29: 200-207https://doi.org/10.12674/ptk.2022.29.3.200

Fig 5.

Figure 5.EF and OUES correlation. EF, ejection fraction; OUES, oxygen uptake efficiency slope.
Physical Therapy Korea 2022; 29: 200-207https://doi.org/10.12674/ptk.2022.29.3.200

Table 1 . Demographic and clinical characteristics of the patients (N = 110).

ParameterData
Sex (male/female)95/15
Age (y)57.4 ± 11.3
BMI (kg/m²)25.1 ± 3.4
Past history
Hypertension54 (49)
Diabetes mellitus27 (25)
Smoking46 (42)
Alcohol37 (34)
Acute coronary syndrome
STEMI53 (48)
NSTEMI26 (24)
HF12 (11)
Angina pectoris37 (34)
Mitral valve prolapse2 (2)
Major invasive management
PTCA93 (85)
CABG2 (2)

Table 2 . OUES and other indicators.

ParameterMean ± SDSE95% CI
OUES1,877.2 ± 630.160.11,994.9–1,759.4
VO2 peak1,506.6 ± 457.243.61,592.0–1,421.1
VE/VCO2 slope33.7 ± 9.00.8635.4–32.0
HRR21.3 ± 10.81.023.3–19.3
EF48.0 ± 11.51.150.2–45.9